Designing and evaluation of Glibenclamide Azadirachta indica mucilage based controlled release matrix tablets
By Hindustan Abdul Ahad, Meghana M., Navya K., Mallika B., Aaslesha A., Srilatha V., Chitta Suresh Kumar
Abstract
The aim of present study was to develop a Controlled release matrix tablets of Glibenclamide with the fruit mucilage of Azadirachta indica and to study its functionality as a matrix former for the controlled release of Glibenclamide from tablet formulations. Physicochemical properties of dried powdered mucilage of Azadirachta indica fruits were studied. Various formulations of Glibenclamide with Azadirachta indica fruit mucilage were prepared by direct compression technique. The formulated matrix tablets were found to have better uniformity of weight and drug content with low statistical deviation. The swelling behavior and in vivo release rate characteristics were studied. The dissolution study proved that the dried Azadirachta indica fruit mucilage can be used as a matrix forming material for making Controlled release Glibenclamide tablets.
Key Words : Azadirachta indica, Glibenclamide, matrix tablets, controlled release
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