Green chemistry is the chemistry of new world, it is also called as sustainable chemistry and green chemistry prevents the use and generation of hazardous substances. Microwave irradiation, use of green catalysts, grinding or milling technique, electrochemical methods, and ultra sound mediated methods are some of the important green chemistry techniques. In the current review we discuss about green synthetic methods used for oxadiazole derivative synthesis. Oxadiazoles are important class of heterocyclic compound with wide therapeutic uses and the techniques discussed here are helpful for the synthesis of more therapeutically relevant novel derivatives of oxadiazoles using more environmentally benign methods.