It is generally agreed that medicinal plants and their products are safer than their synthetic counterparts, however some plant products may prove efficacious but have low therapeutic index or safety margin. Carica papaya fruits, leaves, seed and latex are used medicinally for various ailments. This study was designed to evaluate the potency of aqueous extract of Carica papaya seeds as an anti-inflammatory, antipyretic and antinociceptive in animal models treated orally with 100mg/kg and 1000mg/kg for groups 3 and 4 respectively. Antipyretic studies was done using 15% suspension of Brewer’s yeast in Wistar rats. The antinociceptive activity was done using writhing method in mice and tail immersion method in Wistar rats. The Anti-inflammatory study was done using the xylene-induced ear oedema test and Carrageenan–induced paw oedema. The results showed there was a significant decrease in temperature after 120 mins for both extract groups. For the antinociceptive activity, there was no analgesia with tail immersion test while the writhing test produced 4.5% and 17.4% inhibition for groups 3 and 4 respectively. In the Carrageenan–induced paw oedema, the extract test did not have significant effect while the xylene-induced ear oedema test showed inhibitions of 27.72% and 34.97% for groups 3 and 4 respectively. In Conclusion it can be said that aqueous extract of Carica papaya seed extract has minimal anti-inflammatory and antinociceptive activities with the tested doses in the used animal models, but a better antipyretic activity.