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Genomics of Torque Teno Virus in Diyala Governorate Women with Urinary Tract Infection | Abstract
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Annals of Experimental Biology

Abstract

Genomics of Torque Teno Virus in Diyala Governorate Women with Urinary Tract Infection

Author(s): Nedhal Mahmood Kaleefah, Areej Atiyah Hussein

Due to anatomy and physiological functions, the Torque Teno Virus can cause urinary tract infections in all ages and women more than men.

Objectives: Determine TTV infection rates and genotypes in women with UTIs and correlate them with other parameters.

Methods: Cross-sectional data from women with UTIs was used. Bacterial culture, DNA extraction, microscopic investigation, and phylogenic analysis with specific primers by nested polymerase chain reaction were performed on urine samples.

Results: Eight of 100 samples were TTV-positive. TTV infection was 75% in the statistically significant age group (31-47). Three Staphylococcus aureus (37.5%), two Escherichia coli and Proteus mirabilis (25%), and one Enterococcus fecalis (12.5%) coinfected with positive TTV. Phylogenetic analysis showed that all eight urine-derived TTV DNA isolates were type 1 and 2. According to the closest phylogenetic tree analysis, local isolate No. 6 clustered with reference isolates. One resembled Italian and Brazilian isolates, while numbers 2-5, 3-7, and 4-8 resembled each other and Iranian isolates.

Conclusion: All UTI isolates from Diyala Governorate women were TTV genotypes 1 and 2. Local isolate #6 was similar to Egypt, USA, England, Australia, and Saudi Arabia, while #1 was similar to Italian and Brazilian isolates. Six more isolates resembled Iranians.