New drug delivery systems, such as mucoadhesive systems, can improve drug delivery. This system improves local and systemic effects by maintaining the relationship between tissue and mucosal absorption and release of the drug at the site of action. There are many ways to administer mucoadhesive drugs; most of them are oral, which is still the preferred route by patients due to its convenience. However, the oral route has many disadvantages such as liver front-pass metabolism and intestinal digestion, which affect the absorption of protein and peptide drugs. The oral mucosa provides a strong barrier to drug penetration; one way to improve drug delivery is to use adhesives, and the mucosa has an adequate blood supply and is relatively permeable. Buccal mucosa is a good bioadhesive system because it is a smooth, immobile surface and easy to use. Mucoadhesion can be achieved with mucoadhesive polymers. There are many types of mucoadhesive polymers. Laminate materials are designed to provide chemical release.
