Mefenamic acid is used for the treatment for rheumatoid arthritis, post-operative pain and dysmennoreha.It is chemically
[2-[(2, 3-dimethylphenyl) amino] benzoic acid], an anthracitic
acid derivative, which is a prostaglandin inhibitor. It is water
insoluble, bitter drug with good oral bioavailability (but poor
physico chemical parameters, aqueous solubility) are responsible for its decreased biological activity. It is available as tablets, capsules and suspensions. Nanoparticles have shown significant advancements in delivery of drugs and biomolecules.
The primary objective of this investigation was to develop and
characterize polymeric nanoparticles of Mefenamic acid. Mefenamic acid nanoparticles were prepared by solvent evaporation method and ionic gelation technique by changing the
polymers and stabilizers.