Mefenamic acid is used for the treatment for rheumatoid arthritis, post-operative pain and dysmennoreha.It is chemically [2-[(2, 3-dimethylphenyl) amino] benzoic acid], an anthranilic acid derivative, which is a prostaglandin inhibitor. It is water insoluble, bitter drug with good oral bioavailability (but poor physico chemical parameters, aqueous solubility) are responsible for its decreased biological activity. It is available as tablets, capsules and suspensions. Nanoparticles have shown significant advancements in delivery of drugs and biomolecules. The primary objective of this investigation was to develop and characterize polymeric nanoparticles of Mefenamic acid. Mefenamic acid nanoparticles were prepared by solvent evaporation method and ionic gelation technique by changing the polymers and stabilizers.