A rare case of Salmonella-induced sacroiliitis in a female in her late teens in Asia is presented. The patient had a recent history of diarrhea and fever and was presented with left hip pain and difficulty walking. Blood tests showed anemia, leukocytosis, and positive blood culture for Salmonella typhi. MRI revealed the involvement of the left sacroiliac joint and adjacent muscles. Initial treatment with ceftriaxone did not improve the patient’s condition, and intravenous meropenem was started based on bacterial sensitivity. This case highlights the importance of considering the patient’s medical history and risk factors, and performing a thorough differential diagnosis. Antibiotic resistance is a concern in managing Salmonella infections, and tailored treatment based on susceptibility is crucial. Surgery may be necessary in cases of poor clinical response or when accurate bacteriology is needed, and a multidisciplinary approach involving infectious disease and orthopedic teams is essential for optimal patient care.