In this study the effect of Aloe vera leaf gel consumption with colostrum on the serum total antioxidant capacity of new born calves was investigated at 48h of age (time I) and 72h of age (time II). Thirteen Holstein calves with average of 45kg were divided into two groups randomly and 15 ml Aloe vera leaf gel with colostrum was given to treatment group daily. Blood specimen was collected from jugular vein at both times (I, II). Separated sera were used for determination of total antioxidant capacity. The mean values of serum total antioxidant capacity in control and treatment groups were respectively 338.2 mol/lit and 384.2 mol/lit at time I and 399 mol/lit and 504.4 mol/lit in control and treatment groups at time II. Results indicated that consumption of Aloe vera leaf gel as a natural compound with colostrum could increase serum total antioxidant capacity (TAC) and prevent new born calves from oxidative stress and consequence disease causing economical damages in farm.