The aim of this work is to verify the role played in chromatographic technique by innovative monoliths in mRNA vaccine production: material used, technology, and products for large-scale production. The fact that a great producer uses carbon composite in monoliths is of great interest: carbon fiber reinforcement embedded into epoxy thermoset resin. It also verified the role played by silica products for chromatographic use and their origin (synthetic or natural products like Rice). Related to the product from Rice it is used as a pharmaceutical excipient. Also, in this case, other great chemicals producers on its website for silica gel for chromatography report a reference related to the production of silica from Rice. (not only synthetic so) of interest is the profile of impurity of this product if used in the resin column for purification biopharmaceutical and in particular the carbon content.