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A Novel Polymer-Based Monolithic Capillary with Sulphated ??-Cyclodextrin Chiral for the Enantioselective Pharmaceutical Analysis by Nano-HPLC | Abstract
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Abstract

A Novel Polymer-Based Monolithic Capillary with Sulphated ??-Cyclodextrin Chiral for the Enantioselective Pharmaceutical Analysis by Nano-HPLC

Author(s): Ali Fouad, Mahmoud Sebaiy M, Adel Marzouk A, Samy Ibrahim M, Sobhy El-Adl M

Here we report the first encapsulation of sulphated β-cyclodextrin in organic polymer monolith in capillary columns. The columns were prepared, characterized and investigated for the enantioselective nano-liquid chromatographic separation of 37 racemic pharmaceutical drugs, namely, α- and β-blockers, catecholamines, sedative hypnotics, anti-inflammatory drugs, antifungal drugs, norepinephrine-dopamine reuptake inhibitors, antihistaminics, anticancer drugs, antiarrhythmic drugs and miscellaneous drugs. Acceptable resolution was achieved for some drugs by using reversed phase chromatographic conditions while no separation observed by using normal phase conditions. The developed columns get more economical analysis under environmentally benign conditions.