Adverse Drug Reactions (ADRs) present a serious public health problem that can affect patients, caregivers, pharmaceutical companies, and the health care system as a whole. The objective of the study was to evaluate Adverse Drug Reactions associated with anti-diabetic drugs in antihypertensive patients. The present study was an open, non-comparative, observational study done to monitor ADRs associated with anti-diabetes medications in diabetic hypertensive patients in a territory hospital. A total of 42 adverse drug reactions were observed in 102 diabetic hypertensive patients during December 2016 to June 2017. A high percentage of ADRs occurred in elderly and female patients. Of the 42 ADRs, 22 (52.3%) were mild, 16(38%) were moderate and 4 (9.5%) were identified to be severe. Combination therapy was associated with significantly less occurrence of ADRs, with a total of 17 (40.4%) as compared to monotherapy (n=25, 59.5%). Among the various anti-diabetic drugs used in hypertension patients, metformin were associated with higher number of ADRs (47.6%), followed by glimepride (26.19%), voglibose (16.6%) and pioglitazone (9.5%).