Background: This review summarizes the information about Solid lipid nanoparticle which was a novel approach that brings revolutionary changes in the field of pharmaceutical science. Currently, Lipid-based drug delivery has gained more attention for enhancing the solubility and ultimately bioavailability of poorly water-soluble drugs.
Objectives: This review represents a new approach for enhancing the solubility as well as bioavailability for oral administration of poor solubility of drugs. This review emphasizes the selection of desired ingredients such as lipid, surfactant/emulsifier, and cosurfactant in the formulation of solid lipid nanoparticles. This review also highlights and discusses the examples of solid lipid nanoparticles loaded drugs which results in prolonged-release, high entrapment efficacy, and stability of a drug and also sheds light on drug targeting to specific tissue by preparing solid lipid nanoparticle which maximizes effectiveness and reduces toxicity while avoiding adverse effects on non-target tissues.
Conclusion: Solid lipid nanoparticle was an advanced promising novel drug delivery for improving the bioavailability of poorly soluble drugs which Prolongs the therapeutic activity