It is a non-communicable prolong metabolic diseases marked by high glucose levels consequences from defects and inequality between insulin secretion and insulin action. The chronic condition of hyperglycemia in diabetes patients is associated with chronic destruction and improper retort of various vital organs. Pharmacokinetics accords with absorption, distribution, metabolism, elimination of the drugs. The Pharmacodynamic response pledged with therapeutic returned with nature of the drug. It is treated with several drugs includes sulfonyl ureas, biguanides, alpha glucosidase inhibitors, metaglinides, glucagon like peptides, sodium glucose transporters and insulin injections. Insulin is concealed by beta cells of the pancreatic islets. It consist of 51 amino acids arranged in two chains an A chain 21 amino acids and B chain 30 amino acids that are linked by two disulfide bonds. The insulin preparations consist of long acting, short acting, ultra short acting. The diabetic drugs possess the pharmacokinetic properties,it includes equivalent therapeutic dose of the drugs, plasma protein binding capability, half life ability, exact duration of action,mode of absorption,distribution,metabolism,excretion process. The diabetic drugs shows individual responses impact the insulin release and variations in pharmacokinetic parameters reverse from one drug classification to another drugs.The individual drugs will exert the multiple mechanisms with receptor interactions utilized towards secretion of insulin.