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A solvent-free protocol for the green synthesis of heterocyclic chalcones | Abstract
Scholars Research Library

Scholars Research Library

Der Pharmacia Lettre

Abstract

A solvent-free protocol for the green synthesis of heterocyclic chalcones

Author(s): Sanal Dev and Sunil. R. Dhaneshwar*

Twenty chalcones were prepared by grinding equimolar quantities of (hetero) aryl methyl ketone with (hetero) aryl aldehyde in presence of sodium hydroxide in solvent free condition. Such an attempt has not yet been made or available for the synthesis of heterocyclic chalcones mentioned in this work. The synthesis was found to be simple, efficient in terms of short reaction time, excellent yields and afford single product as indicated in TLC. The synthesized compounds were characterized by means of their IR, 1H NMR spectral data and elemental analysis. This method may be a promising alternative to the conventional methods.


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