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An improved synthesis of Tazobactam and its related impurities | Abstract
Scholars Research Library

Scholars Research Library

Der Pharmacia Lettre

Abstract

An improved synthesis of Tazobactam and its related impurities

Author(s): Narsihma Reddy. B, a,b Narayan G. K. A. S. S, a* Ravindra K. Hunnur, a Kaushik V.K, a Badarinath Gupta, a Mamatha Bobbali a and Aminul Islama

An efficient improved synthesis of Tazobactam 1 (a β-lactamase inhibitor), is described here. This efficient process provides 40-45% higher yield of 1 in comparison to the first generation manufacturing process and which is concise and amenable for large scale synthesis. Process related impurities of Tazobactam diphenylmethyl ester 8 have been identified by LC-MS. Further these related impurities are synthesized, isolated and characterized by spectral studies.


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