In this study, the analgesic, and antipyretic effects of aqueous extract obtained from Clerodendrum inerme leaves, the so-called AECI was investigated. Analgesic effect of AECI was evaluated by Hot plate, Tail Flick and Tail immersion methods in albino rats. Antipyretic activity of AECI was evaluated by milk-induced hyperpyrexia in rabbits. The AECI produced significant (P<0.001) analgesic activity in all models. Further, the AECI potentiated the Diclofenac sodium-induced analgesic effect in albino rats. Treatment with AECI showed a significant (P<0.001) dose-dependent reduction of pyrexia in rabbits. The results suggest that AECI possess potent analgesic and antipyretic activity.