Introduction: Grape seed belongs to the plant family of plantain family Plantaginaceae, The plant is native to most of Europe and northern and central Asia, but has widely naturalized elsewhere in the world. The aim of this study was to overview pharmacological properties of grape seed. Methods: This review article was carried out by searching studies in PubMed, Medline, Web of Science, and IranMedex databases. The initial search strategy identified about 102 references. In this study, 44 studies were accepted for further screening and met all our inclusion criteria [in English, full text, therapeutic effects of Grape seed and dated mainly from the year 1992 to 2016.The search terms were “Grape seed”, “therapeutic properties”, “pharmacological effects”. Result: It is commonly used for its Chemotherapeutic effect, Antioxidant effect, Antitumoral effect, Biological effect, Antiviral and Immunoenhancing effect, Mechanical effect Antimicrobial effect, Hematopoietic effect, Anti-cancer effect, Antioxidant effect, wound healing, Neutrophil Respiratory Burst Conclusion: Although the results from this review are quite promising for the use of Grape seed as a multi-purpose medicinal agent, several limitations currently exist in the current literature. While Grape seed has been used successfully in Ayurvedic medicine for centuries, more clinical trials should be conducted to support its therapeutic use. It is also important to recognize that Plantago may be effective not only in isolation, but may actually have a potentiating effect when given in combination with other herbs or drugs.