Introduction: Symphytum officinale L. belongs to the plant family of plantain family Plantaginaceae, The plant is native to most of Europe and northern and central Asia, but has widely naturalized elsewhere in the world. The aim of this study was to overview pharmacological properties of Symphytum officinale L. Methods: This review article was carried out by searching studies in PubMed, Medline, Web of Science, and IranMedex databases. The initial search strategy identified about 102 references. In this study, 44 studies was accepted for further screening and met all our inclusion criteria [in English, full text, therapeutic effects of Symphytum officinale L. and dated mainly from the year 1992 to 2016.The search terms were “Symphytum officinale L.”, “therapeutic properties”, “pharmacological effects”. Result: the result of this study indicated that Symphytum officinale L. possess anti-cancer and osteoarthritic pain activity. Conclusion: based on the result, Symphytum officinale L. was shown to be effective in carcinoma treatment as well as being effective in relieving pain and stiffness and in improving physical functioning and were superior to placebo in those with primary osteoarthritis of the knee without serious adverse effects.