From previous studies, radish and yam bean are known to reduce blood glucose level. The objective of this study was to evaluate the effects of combination of radish extract and yam bean extract in reducing blood glucose level. Diabetic mice was induced by intravenous administration of a single dose of 55 mg/kg alloxan. The mice were divided into seven groups: normal control, diabetic control, gliclazid 5.2 mg/kg, radish 200 mg/kg, yam bean 100 mg/kg, combination with high dose (radish 200 mg/kg and yam bean 100 mg/kg), combination with low dose (radish 100 mg/kg and yam bean 50 mg/kg). The mice were treated with the extracts for 21 days. Blood glucose level was determined every 7 days and at the end of treatment, the β-cell pancreas was observed by Gomori staining. The result showed that radish at dose of 200 mg/kg, combination of high dose and low dose could significantly reduced blood glucose level (45.50%, 34.33%, 50.22%, respectively) compared to diabetic control (p<0.05). In conclusion, radish and combination of radish extract and yam bean extract have antidiabetic activity on damage of pancreas.