A novel series of 5-(Substituted-phenyl)-3-(furan-2-yl)-4,5-dihydro-1H-pyrazole were already prepared from the reaction of hydrazine hydrate with many chalcone in the presence of ethanol. All novel compounds were screened for their In-vitro anti-inflammatory activity by using egg albumin/ protein denaturation method at various concentrations. On the bases of structure-activity relationship (SAR) study it was found that amongst to all other compounds, 4-(3-(furan-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)aniline (7) found to be the most potent with the IC50 value of 419.05 μg/ml as compared with standard drug Diclofenac sodium.
