The purpose of the present study was to investigate the anti-inflammatory properties of ethanolic extract of the leaves of Holoptelea integrifolia Planch. (EHI). The different anti-inflammatory models were used. The EHI at dose (250 and 500mg/kg p.o) was given to observe percentage inhibition of paw oedema which were comparable with indomethacin (10mg/kg p.o) used as a reference drug. The extract (500mgkg-1 b.w) exhibited maximum anti-inflammatory effect with carrageenan, dextran, histamine, serotonin and cotton pellet method respectively. A significant percentage inhibition of paw oedema by the EHI as compared to standard drug suggests its usefulness in acute and chronic anti-inflammatory models.