Metal nanoparticle-drug interaction is indeed an unexplored area of research and guarantees some effective outcomes pertaining to improvements in drug characteristics. This area of research would really bring glory to drug discovery owing to simplicity, efficiency, and organ targeting talent of metal nanoparticles. Various drugs get adsorbed on AgNps, thus increasing their solubility in water solution. This novel approach where the physicochemical properties of the drugs adsorbed on noble metal nanoparticles surface will allow us to deep in the design of new drug release systems with the potential to develop the clinical efficiency of the therapeutic effect of drug molecules. The present investigation reported a green method for synthesis of elemental silver i. e. Silver nanoparticles (AgNps) using gelatin and cow urine. Synthesized AgNps were subsequently evaluated for its effect on the insolubility of Ibuprofen. TEM of AgNps showed spherical shape and size distribution was significantly in the range of 10 to 20 nm. SAED pattern showed diffused rings pattern. XRD revealed the insignificant increase in the crystallinity of the AgNps. IR supports the evidence of the contribution of amide linkage in the process of reduction. DSC supports the evidence of elemental silver entrapped in helical strands of proteinous gelatin. Phase solubility study was carried out in and off a presence of AgNps which revealed that an increase in the concentration of AgNps may affect positively poor solubility of Ibuprofen. Instrumental analysis performed in the present investigation along with the SAED pattern may reveal the solubility enhancement was the consequence of adsorption phenomenon.