Present work is a continuation of our previous work where 78 pre- (39) and postmenopausal (39) women were recruited. Each group was further divided into; non-obese normal (10), obese normal (10), non-obese hypertensive (10), and obese hypertensive (10). Body mass index was calculated as per WHO and hypertensive status was determined following JNC (VII) guidelines. After ensuring fasting for 12 hours, blood sample of 5 ml was collected in sterile tubes from anti-cubital vein. Serum was separated, aliquots were made and serum samples were stored in freezer for the estimation of lipid profile and estradiol levels. Estradiol was assayed by competitive ELISA using Estradiol Kit manufactured by Adaltis Italia (Italy) for the previous work and rest of the sample was stored for assaying lipid profile for the present work. Lipid profile was estimated from the stored blood samples using the commercially available kits. The mean values of TC, TG and LDL-C were significantly higher whereas, mean value of HDL-C was significantly lower in obese normal subjects as compared to their non-obese counterparts in both pre- and postmenopausal groups. As compared to premenopausal, the situation was bad in postmenopausal women. Similar was the status in hypertensive subjects but the situation aggravated in hypertensive subjects as compared to their normal counterparts. The correlation exists between lipid profile and BMI and estradiol. Decreased levels of estradiol in obese and hypertensive subjects reflect the role of the hormone in making the situation worst. May be this is the reason, the prevalence of hypertension increases in obese as well as postmenopausal women.