Automatic control of physiological state for future clinical treatment: Necessity of mathematical models | Abstract
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Journal of Computational Methods in Molecular Design


Automatic control of physiological state for future clinical treatment: Necessity of mathematical models

Author(s): Tomohiko Utsuki

In operating room, emergency room and intensive care unit, medical staff have so heavy burden that they cannot from time to time have sufficient time and attention for medical treatment. Especially, many pursuits tasks, which demand advanced knowledge and competencies to clinical staff, are required for the management of physiological kingdom pertinent to life-support. Thus, it is very beneficial to enhance and apply automated control systems of physiological nation for alleviating such burden in clinical treatment. A few of structures have been developed and attempted to apply to patients in medical treatment, such as computerized control structures of blood-sugar level, hemoglobin oxygen saturation in artery and concentration of carbon dioxide in alveoli. Notably, an automated manage machine of intelligence temperature was once developed and clinically applied. The designing and development of such device typically require a model of applicable physiological state as the managed object in the simulation test of the system or as the thing delivered in the system's controller, because heuristic device designing primarily based on experiments on animals is not allowed ethically. On the stage of fundamental development, even if a gadget is designed through a method except using model, such as ‘Fictitious Reference Iterative Tuning’, a model of physiological nation is integral for verification of the system by simulation. In this presentation, a number automatic control systems of physiological kingdom are including every mannequin used in the development. Moreover, a model of cerebral blood circulation and extracellular fluid migrations in cerebral tissue are explained, which are built as the elements of the integrative mannequin of brain’s physiological state. This integrative model is required for developing an built-in manipulate system, by which intracranial pressure, cerebral blood drift and intelligence temperature will be robotically managed in consideration of the mutual consequences for advanced Genius resuscitation.

Over the ultimate 10 years, ‘Systems Biology’ has targeted on the integration of biology and remedy with statistics technology and computation. The modern-day undertaking is to use the discoveries of the last 20 years, such as genomics and proteomics, to develop focused therapeutical strategies. These strategies are the result of perception the aetiologies of complex diseases. Scientists predict the records will make customized medicine swiftly available. However, the statistics need to be regarded as a tremendously complex system comprising more than one inputs and comments mechanisms. Translational remedy requires the purposeful and conceptual linkage of genetics to proteins, proteins to cells, cells to organs, organs to structures and structures to the organism. To help understand the complicated integration of these systems, a mathematical model of the complete human body, which accurately hyperlinks the functioning of all organs and systems together, could grant a framework for the development and testing of new hypotheses that will be necessary in scientific outcomes. There are several efforts to develop a ‘Human Physiome’, with the strengths and weaknesses of every being here. The development of a ‘Human Model’, with verification, documentation, and validation of the underlying and integrative responses, is crucial to grant a usable environment. Future development of a ‘Human Model’ requires integrative physiologists working in collaboration with different scientists, who have information in all areas of human biology, to improve the most accurate and usable human model. Biomedical researchers can use integrative physiological models to higher apprehend the necessary relationships hidden in the complexity. Translational Research has made an integrative evaluation of human physiology more relevant. The explosion of data over the final 20 years gives novel opportunities to strengthen new clinical treatments. New applied sciences – DNA sequencing, imaging, proteomics, etc. – supply huge amounts of new facts about the human body. The capability to extract beneficial data from these statistics will lead to customized remedies for disease, such as most cancers and haematological and metabolic disorders. These data have delivered about the necessity of new methods of analysis. Genetic evaluation suggests which genes may also be important for clinical outcomes; however, the physiological relevance of changes in genetic make-up is no longer clear. This ambiguity necessitates goals for the integrative analysis.