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Bioanalytical method validation of montelukast salt in human plasma using LC-MS/MS method | Abstract
Scholars Research Library

Scholars Research Library

Der Pharmacia Lettre

Abstract

Bioanalytical method validation of montelukast salt in human plasma using LC-MS/MS method

Author(s): Anil Kumar Veeragoni, Vasudeva Murthy Sindgi and Shoba Rani Satla

Sodium salt of Montelukast is the leukotriene receptor antagonist used for the treatment of asthma and allergies. LC-MS/MS method was developed to determine Montelukast sodium in human plasma. The quality control samples were prepared between 100 and 12000 ng/mL. Plasma concentration samples were prepared in between 2.5 ng/mL and 600 ng/mL. The method was found to be linear in the range of 2.5 ng/mL and 600 ng/mL.The concentration vs. ratio of Montelukast sodium/ IS has y = 0.004x + 0.135 with R2= 0.991.The procedure followed in this method has the least concentration i.e. LLOQ is very low than previously reported methods and is suitable for estimation of Montelukast sodium in human plasma.


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