Heavy metals are recognized as cumulative toxic substances causing serious health hazards to man depending on their concentration. Forty Common Carp (CyprinousCarpio, L.) were collected from Abbassa Sharkia government and fed commercial fish diet. Thirty fish were exposed to cadmium chloride 1p.p.m.) and 30?¢????¦ temp. For 21 days. Ten fish were kept without treatment (control). Hematological analysis of the exposed group demonstrated a marked elevation in serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, serum glucose, urea, creatinine, sodium, potassium, and phosphorus, while serum calcium, haemoglobin and PCV were reduced . Kidney, spleen, and gills, which were reflected on the biochemical and hematological parameters. Heavy metals induced cumulative effect; therefore, equivalent lesions of fish may occur in humans. Moreover, immune suppression could play an important role in predisposing for further infections conditions. After 30 days’ treatment with probiotic it returns to normal parameters
