Scholars Research Library

Scholars Research Library

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Der Pharmacia Lettre


Biologically Active Azoles: Synthesis, Characterization and Antimicrobial Activity of Some 1-substituted imidazoles

Author(s): Baskar Lakshmanan, Papiya Mitra Mazumder, Dinakar Sasmal, Swastika Ganguly

A few 1-substituted imidazoles 1(a-d) and 2(a-d) have been synthesized and characterized on the basis of elemental analysis, FT-IR, 1H-NMR, DART-MS spectral data. The synthesized compounds were screened for their in vitro growth inhibiting activity against different strains of bacteria and fungi viz., Staphylococcus aureus, Bacillus subtilis, Streptococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Candida albicans, Aspergillus niger and Penicillium chrysogenum (10 and 50?¼g/ml) and the results were compared with the standard antibiotic Ciprofloxacin and ketoconazole (10?¼g/ml) using agar diffusion technique.