Volatile components of the aerial parts of Pulicaria arabica have been studied by gas chromatography–mass spectrometry to afford 24 compounds representing 99.99 % of the crude oil. The major components were found to be Bicyclo (4.4.0) Dec-1-ene, 2-Isopropyl-5-methyl-9-methylene (17.23%), α- cadinene (13.0 %), 1H-Indene , 1- ethylideneoctahydro (13.24%), β-Bourbonene (7.34 %), and α-Muurolene (5.94%). The antimicrobial activities of the essential oils were evaluated by disk diffusion method and tested against 11 strain Gram-positive and Gramnegative bacteria and revealed an average antibacterial activity. In vitro antioxidant activity of the essential oils was carried out using DPPH (1,1-diphenyl-2 picrylhydrazyl) radical scavenging assay. The results indicated a moderate capacity.