Hypericum perforatum is native to parts of Europe and Asia but has spread worldwide as a cosmopolitan invasive weed, including to temperate regions of India, China, Canada, Africa, and the United States. The aim of this study was to overview its therapeutic effects. This review article was carried out by searching studies in PubMed, Medline, Web of Science, and Iran Medex databases .The initial search strategy identified about 98 references. In this study, 42 studies was accepted for further screening and met all our inclusion criteria [in English, full text, therapeutic effects of Hypericum perforatum and dated mainly from the year 1987 to 2016.The search terms were “Hypericum perforatum”, lemon balm, “therapeutic properties”, “pharmacological effects”. It is commonly used for antimicrobial effect, neuroprotective effect, anti-depressive effect, antioxidant effect, menopause, dental practice, anti-inflammatory, wound healing effect, anti-cancer effect, anti-herpes effect, phototoxicological effect. Hypericum perforatum is widely used for therapeutic and non-therapeutic purposes that trigger its significant value. Various combinations and numerous medicinal properties of its extract, oil, and leaves demand further and more studies about the other useful and unknown properties of this multipurpose plant.