Introduction: Coffee belong to family Rubiaceae, indigenous to tropical Africa, and Madagascar, India. The purpose of this review article was to overview the relationship between Coffee consumption and prostate, colorectal and, liver cancer. Methods: This review article was carried out by searching research in PubMed, Medline, Web of Science, and Iran Medex databases. The primary research strategy reported 99 references. In this study, 63 studies were accepted for further screening and met all our inclusion criteria [in English, full text, prostate, colorectal and, liver anti-cancer effects of blueberries and dated mainly from the year 2009 to 2016.The search terms were “Coffee”, “prostate, colorectal and, liver anti-cancer effects”, “pharmacological effects”. Result: although moderate coffee consumption is beneficial in treatment and prevention of many diseases, it was reported that long term coffee intake contributes to different kinds of cancer most notably prostate, colorectal and, liver cancer. While some studies reported that that coffee consumption increases the risk of colon cancer, some others suggested that coffee consumption decrease the risk of cancer. Besides, there are some studies reporting that there is no association between coffee intake and incidence of cancer. Conclusion: the result of this study regarding to the association between coffee consumption and incidence of different kinds of cancer was quite varied. Coffee consumption increases the risk of colon cancer among men while it may be inversely associated with risk of colorectal cancer in a dose-response manner. Coffee intake is associated with reduced risk of liver and prostate cancers.