Liposomes have appealing biological properties, including the biocompatibility and biodegradability. They are ensured as active vectors because of their ability to enhance the encapsulant performance by expanding drug solubility and stability, conveying encapsulated medications to specific target sites and showing sustained drug release. The objective of the present study is to develop ketoconazole liposomes with commercial Soya lecithin and enriched Soya Lecithin and make a comparative study. Liposomes were prepared by film hydration technique. The prepared liposomes were evaluated for optical microscopy, entrapment efficacy, In Vitro release studies, Scanning Electron Microscopy and FTIR-Spectroscopy. Encapsulation efficiency of liposomes showed good amount of loading into the vesicles among all liposomal formulations E-F4 showed highest encapsulation efficiency 92.36 %. FTIR study proves that there is no interaction between pure drug and excipients used in the formulation. SEM images shows the surface of the vesicles was smooth and round and size of E-F4 particles are in the range of 149μm - 306μm & for E-F5 the size of the particles are in the range of 136-265μm. In-vitro diffusion studies were performed for liposomes, the results showed that highest percentage 87.39 % of drug release in 24 hrs was shown in for liposome formulation E-F4.