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Conventional and microwave assisted synthesis of novel pyrimidine derivatives as antimicrobial and antitubercular agent | Abstract
Scholars Research Library

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Abstract

Conventional and microwave assisted synthesis of novel pyrimidine derivatives as antimicrobial and antitubercular agent

Author(s): Dipen K. Sureja, Sandip P. Dholakia and Kantilal R. Vadalia

A simple and efficient approach towards single step synthesis of 6-amino-5-cyano-2-(hydroxy/mercapto)-4- substitutedpyrimidine derivatives has been developed by three component condensation of aromatic aldehydes, malononitrile and urea or thiourea using conventional heating and microwave irradiation technique. Some of these novel derivatives showed moderate to potent in-vitro antibacterial, antifungal and antitubercular activity.


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