In recent times different injurious and terminal diseases with unknown cause and devastating effects have infringe into human lives. One of these diseases is the renal failure in humans which may be caused by edible chemicals and other edible earth materials such as potash (Kaun-K2CO3). In order to unravel this increasing phenomenon in humans, the effects of potash on the kidney of Wister rats was investigated. Twenty (20) Wister rats were used for the study and buy carisoprodol online grouped into four categories marked A, B, C and D with 5 rats in each group. The potash (hydrated sodium carbonate - dried lake salt.) used was obtained from the regular Ekpoma market in the central part of Edo state. The rats in groups B, C, and D were fed with 3g, 6g, and 9g concentrations of potash respectively mixed in growers mash for a period of three weeks in order to investigate the effects of this compound on the kidney. The results of this study showed that at varying concentration of potash, there were progressive tubular and carisoprodol vascular changes, cellular necrosis and glomerular degeneration and this imply that potash is cytotoxic to the kidney tissues. Therefore, excessive consumption of this earthy material (potash-Kaun) may lead to its accumulation that could cause severe and irreparable damage to the kidney and disrupt normal body functions which may eventually lead to loss of life.