Scholars Research Library

Scholars Research Library

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Der Pharmacia Lettre


Design and development of gastroretentive floating microspheres of glipizide

Author(s): Amit K. Joshi, Tarak. J. Mehta, M. R. Patel, K. R. Patel and N. M. Patel

The floating or hydro dynamically controlled drug-delivery systems are useful to increase the retention time of the drug-delivery systems for more than 12 h. Unfortunately floating devices administered in a single unit form (such as hydrodynemially balanced system)are unreliable in prolonging the GRT owing to their ‘all-or–nothing” emptying process and thus they may causes high variability in bioavailability and local irritation due to large amount of drug delivered at a particular site of the GIT. Glipizide is a second-generation sulfonylurea having short biological half-life (3.4 ± 0.7 hours). Moreover, the site of absorption of glipizide is in the stomach2. The present study reports the development of drug-loaded floating microspheres of acrycoat S100 (acrylic resin) with an internal hollow structure by a solvent diffusion and evaporation method. The yield of microspheres depended on the diffusion rate of alcohol in the organic phase. The mixing ratio of components in the organic phase affected the size and the yield of Microspheres. Direct introduction of the organic phase into the aqueous phase though a glass tube also significantly improved the yield by avoiding the contact of organic phase with the surface of water. The microspheres produced exhibited good encapsulation efficiencies and micromeritic properties for formulation as single-unit dosage forms. The microspheres were having lower densities. Encapsulation efficiency of microspheres is around 90%. This is because of the low solubility of glipizide in aqueous solution