Tizanidine is an alpha-2-adrenergic agonist and act by increasing the pre-synaptic inhibition of spinal motor neurons. Natural polymers have gained profound importance as lead compounds for delivery of drugs in treatment of various infections. The aim of this study was to formulate Tizanidine hydrochloride into a buccoadhesive tablet, using natural polymers in order to enhance its bioavailability. In the present study four formulations (F14-F17) were prepared by using natural polymer guar gum and some additives such as aspatanase, lactose and magnesium state. Among all the formulations F17 formulation containing guar gum as a quantity of 50 mg as optimized formulation having 86.78 % in 11 hrs showing sustained release based on invitro drug release, swelling and bioadhesive strength.