Design and evaluation of fast dissolving tablets for rizatriptan benzoate | Abstract
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Design and evaluation of fast dissolving tablets for rizatriptan benzoate

Author(s): S. Vidyadhara, R. L. C. Sasidhar*, T. Balakrishna, S. Vikas and M. Bhaskar

Rizatriptan Benzoate is potent anti migraine drug having agonist activity at the 5-hydroxytryptamine (5-HT) 1B and 5-HT 1D receptor. It commonly used for relief of headaches in treatment of migraine. Conventional tablets of RZT are not capable of rapid action, which is required for immediate relief from migraine pain. The aim of present work is to formulate and evaluate fast dissolving tablets of Rizatriptan Benzoate prepared by effervescent and sublimation methods using effervescent agents like sodium bicarbonate & citric acid, super disintegrants like Cross carmellose sodium, Avicel PH 112 as diluents and menthol as sublimating agent. The prepared tablets were evaluated for uniformity of weight, thickness, friability, content uniformity, hardness, disintegration time, wetting time and for in vitro drug release. Further the tablets were characterized by fourier transform infra red spectroscopy and differential scanning calorimetry. Among all the formulations the tablets prepared by sublimation methods using menthol and Cross carmellose sodium as super disintegrant and Avicel PH 112 as diluents showed faster disintegration and rapid drug release.