The objective of the present investigation was to design and evaluate the oral controlled release matrix tablets of ambroxol hydrochloride by using various natural matrix former gums such as Tara gum and Locust bean gum separately. Tablets were prepared by wet granulation method. The prepared tablets were further evaluated for uniformity of weight, hardness, friability, thickness, content uniformity, In-vitro dissolution, drug-excipients interactions, swelling index study also carried out. The FT-IR studies revealed that there was no chemical interaction between drug and excipients. Among different formulations, F-3 and F-6 which contain Tara gum and Locust bean gum with drug: polymer ratio as (1:3) and exhibited precise controlled release of drug over a prolonged period of 12 hrs. The in- vitro dissolution data obtained for various formulations were fitted into zeroorder, first order, Higuchi’s and Peppas kinetic models. The majority of designed formulations displayed zero order release kinetics and Korsmeyer and Peppas equation give release pattern with values of (n = 0.534 – 0.570) indicating non-fickian or Anomalous types of diffusion takes place through matrix of Tara gum and Locust bean gum. The optimized formulations F-3 and F-6 were subjected to stability studies for three months at 250C/60%RH and 400C/75%RH as per ICH guidelines and result does not shows any change in physical parameters and in-vitro release studies. The result demonstrates the feasibility of natural gums in the development of oral matrix tablets for controlled delivey of ambroxol hydrochloride.
