Scholars Research Library

Scholars Research Library

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Der Pharmacia Lettre

Abstract

Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for Gliclazide

Author(s): Vikrant Wankhade, Kiran Tapar, Shrikant Pande, Nishant Bobade

Self-nanoemulsifying drug delivery systems (SNEDDS) were developed with the objective to overcome problems associated with the delivery of Gliclazide, a poorly bioavailable, anti-diabetic having pH dependant solubility. Solubility of Gliclazide in oily phases and surfactants were determined to identify components of SNEDDS. Various surfactants and co-surfactants were screened for their ability to emulsify selected oily phases. Ternary phase diagrams were constructed to identify area of nanoemulsification for the selected systems. The influence of Gliclazide and pH of dilution medium on the phase behavior of selected system were assessed. The globule size of optimized Gliclazide SNEDDS in various dissolution media was determined to check the effect of pH on its behavior. The optimized Gliclazide SNEDDS needed surfactant content less than 55% and yielded nanoemulsion of mean globule size 146 nm, which was not affected by the pH of dilution medium. The optimized SNEDDS released the Gliclazide drug completely within 20 min irrespective of the pH of dissolution medium.
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