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Design and synthesis of 2-pyrazoline derivatives | Abstract
Scholars Research Library

Scholars Research Library

Der Pharmacia Lettre

Abstract

Design and synthesis of 2-pyrazoline derivatives

Author(s): Abu Baker M. Osman, Azhari H. Nour, Daffallah M. H. Ali, Hassan A. Osman and A. E. M. Saeed

Some substituted pyrazoline -1-carbothiamides have been synthesized using cyclization reaction of chalcones and thiosemicarbazide. Some acetophenone derivatives were treated with appropriate substituted benzaldehydes in the presence of ethanol as solvent and sodium hydroxide as basic medium to furnish some substituted chalcones. These chalcones were treated with thiosemicarbazide yielding substituted 3,5-diphenyl-4,5-dihydro-1-H-pyrazole-1- carbothioamides which are named as 2-pyrazoline derivative. The reaction progress for all synthesized compounds was checked by thin layer chromatography (TLC) and melting point techniques, the structure of synthesized compounds were confirmed using IR, 1HNMR, and GCMS.


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