The aim of our research work is to promote mixed solvency concept by formulating the topical solution (lotion) and topical gel of poorly water soluble drug naproxen by decreasing the individual solubilizer concentration in small proportion for expected enhancement of drug solubility in water. For poorly water soluble drug naproxen, solubilizers such as sodium benzoate, sodium citrate, sodium caprylate, arginine, valine, benzoic acid, poloxamer 407 and niacinamide has been used in combinations as mixed solvent systems. The enhancement of solubility in selected mixed solvent blend was more than 60 folds. The procured sample of naproxen was characterized by melting point, UV spectroscopy, IR and DSC studies. The formulation was designed, formulated and evaluated for various properties of solution and gels such as pH, freeze thaw study and thin layer chromatography, physical appearance and Invitro drug relaease studies were performed using franz diffusion cell. Mixed solvency concept was successfully utilized for formulation development of marketable product of Naproxen.
