Hydrophilic matrices involving natural polysaccharides are an interesting option for developing sustained release formulation. One of such polysaccharides is Tamarind seed polysaccharide (TSP) isolated from seedkernel of Tamarindusindica.TSP is used as the binder, mucoadhesive, antiviral, antitumor, floculant, gellingagent, suspendingagent, solubility enhancer. The main aim of this study is to use TSP as film forming agent. The TSP is isolated and characterised for identification tests,organoleptic characters, solubility, swelling index, microbiological tests andIR spectra and was found to be no incompatability with the alfuzocinHCl by the FTIR studies. The transdermal films of TSP were prepared ( f1 tof8). The prepared films were evaluated for thickness, uniformity of weight,Drug content determination, moisture content, Percentage moisture loss, Folding Endurance, flatness, Water vapour transmission rate, In-vitro diffusion studies and all the values were found to be satisfactory. Among all formulationsf5 was found to be having good release and all other properties comparing to other formulations and it is following the super case II release. The order of release was found to be f5>f1>f6>f7>f8>f2>f3>f4.