This study was carried out to determine the PCBs levels in skin and muscle tissues of Esox lucius in Abkenar (western area of Anzali wetland) in autumn (December 2009). Water samples, sediment and suspended particles in water and E.lucius caught in Abkenar zone were submitted to four selected stations for analysis. The biometric values including total weight and length were measured for the fish samples. All the samples obtained i.e. water, sediment and suspended particles as well as the fish sample were transferred to the laboratory according to the Moopam standard . The skin and muscle tissues of E.lucius were separated and prepared according to the same standard and the PCBs level was analyzed by using a Gas Chromatography (GC–ECD) equipped with a Ni63 detector. Average concentration of PCBs in E.lucius skin and muscle samples were 24.36 and 14.36 ng/g dry weight, respectively. The average coefficient of variation (C.V) of PCBs concentration in E.lucius skin was more than that of the muscle. A highly significant difference was observed between the muscle and skin tissues of E.lucius (P<0.000; n=9). Also, a significant difference was observed between PCBs levels in water and sediment samples (p<0.000; n=12) and particles suspended in filtered water (p<0.0001; n=12). Moreover, there was a very strong positive correlation found between the PCBs levels in water and the filtered suspended particles in water (p=0.0001; r=0.980; r2=96%; n=12). Level of accumulation of biological in skin texture of E.lucius was about 5835.69 ppb and in its muscle texture was 3440.58 ppb. Maximum level of average PCBs measured in the fish tissues in autumn (maximum 0.03653 ppm. and minimum 0.01025 ppm) was less than those of the FDI standard and Food Standards Australia/NZ MRL and was more than that of USEPA standard (skin texture of E.lucius). The most dangerous isomers of PCB as indicators of PCB in polluting seas and particularly the coastal region, like seaport and estuary are studied (PCB 28,52,101,138,153,180), in skin texture and muscle is being investigated that the maximum density of mentioned dangerous isomers in autumn in skin and muscle of E.lucius was more in isomers with chlorine (related to 153 PCB that its maximum in sample number 9 (3.64ppb) but in measurement environment of water, suspended particles of water and sediment in isomers or less chlorine (PCB 52) had the highest density. The maximum daily consumption limit of E.lucius muscle tissue by a person of 70kg weight in a day averagely is 0.026kg.