A simple, rapid and precise Reverse Phase High Performance Liquid Chromatographic method was developed for simultaneous estimation of Eperisone hydrochloride and Naproxen sodium in newly developed tablet dosage form by reverse phase HiQSil C-18 column (250 mm, 4.6 mm, and 5 μm). The sample was analyzed using: Acetonitrile: 10mM n-hexane sulfonic acid buffer (70:30 v/v), as a mobile phase at a flow rate of 1.0 mL/min. and detection at 250 nm. The retention time for Eperisone hydrochloride and Naproxen sodium was found to be 2.77 min and 9.56 min, respectively. The linearity of developed method was achieved in the range of 1-10 μg/mL for Eperisone hydrochloride and 1-25 μg/mL for Naproxen sodium. The method was validated in terms of accuracy, precision, linearity, limit of detection, limit of quantitation, robustness and ruggedness as per ICH guidelines.