Scholars Research Library

Scholars Research Library

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Der Pharmacia Lettre

Abstract

Development and Validation of Spectrophotomtric Method for the Determination of Risperidone

Author(s): B. Narayana and Divya N. Shetty

A simple and sensitive method for the spectrophotometric determination of risperidone (RIS) is proposed. The method is based on the oxidation of the drug using chloramine-T (CAT) and the excess oxidant is determined by either xylene cyanol FF (XCFF) or malachite green (MG), the absorbances of which are measured at 612 or 619 nm for RIS-XCFF and RIS-MG respectively. Under the proposed optimum conditions Beer’s law is obeyed in the concentration range of 2.00- 26.00 and 2.00-18.00 μgmL-1 and the molar absorptivities are calculated to be 4.37×104 and 3.93×104 Lmol-1cm-1 for RIS-XCFF and RIS-MG systems. The limit of detection and quantification for RIS-XCFF and RIS- MG are found to be 0.891, 2.702 μgmL-1 and 0.529, 1.605 μgmL-1 respectively. The proposed method is applied successfully for the pharmaceutical formulations.


javgrown.com scatvids.club javvids.com