An accurate, rapid, highly sensitive, economic and reproducible UV-Visible spectrophotometric method was developed and validated for the estimation of Tapentadol Hydrochloride in its pharmaceutical formulation. The method was validated as per International Conference on Hormonization (ICH) Q2A and Q2B guidelines. Tapentadol Hydrochloride was monitored at 275nm with UV detection; there is no interference of diluents at 275nm for Tapentadol Hydrochloride. The method was linear (r2=0.9992) at concentration ranging from 20-100μgmL-1, precise (intra and inter-day% RSD values<2%), accurate (mean recovery=101.3%) specific and robust. The proposed method was successfully applied for the quantification of bulk and active pharmaceutical present in tablet dosage form.