Der Pharmacia Lettre
Praveen Koshy, Sharad Pacharane, Amol Chaudhry, Kisan Jadhav, Vilasrao Kadam
Poor aqueous solubility is a major issue in the pharmaceutical industries for dosage form
development. A limiting factor for in vivo performance of these drugs after oral administration is
their inadequate ability to be wetted by and dissolved into the fluid in the gastrointestinal tract.
Particle engineering techniques are tools to modify the physicochemical, micromeritics and
biopharmaceutical properties of the poorly soluble drug and hence solubility. In the present
review different approaches of particle engineering technology like mechanical techniques,
evaporative precipitation into aqueous solution, controlled precipitation, supercritical fluid
technologies, freezing techniques, sonication technology etc. which improve the aqueous
solubility of drugs are discussed.