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Effect of dietary consumption of three Nigerian edible plants on the liver histology and enzymatic indices in induced anaemic adult wister rats | Abstract
Scholars Research Library

Scholars Research Library

Der Pharmacia Lettre

Abstract

Effect of dietary consumption of three Nigerian edible plants on the liver histology and enzymatic indices in induced anaemic adult wister rats

Author(s): Theresa E. Isamoh*, Mokutima A. Eluwa, Akpanthah O. Akpantah and Theresa B. Ekanem

Studies have demonstrated the apparent therapeutic and preventive nature of various plants consumed as food. Garlic, garden egg and groundnut are popularly consumed as diet or food supplement. The hepatoprotective potentials of combined consumption of these dietary plants on phenylhydrazine-induced anaemic rats were investigated. Twenty five Wister rats were divided equally into five groups. Group 1 served as the negative control while Group 2 was induced with anaemia and served as the positive control. Groups 3, 4 and five were anaemic; group 3 rats were fed with combined diet of garlic, garden egg and groundnut, group 4 rats fed with diet of garden egg and group 5 fed with diet of groundnut. The liver enzyme and tissue histology were determined using standard procedures. Histological alteration was observed in liver of rats in positive control as compared to negative control. Normal cytoarchitecture of liver was observed in rats in groups 3, 4 and 5. The activity of alkaline phosphatase (ALP) was not significantly (p<0.05) different among the five groups. Alanine aminotransferase (ALT) significantly (p<0.05) increased in Group 3, Group 4 and Group 5 as compared to the negative control and significantly (p<0.05) increased in Group 3 and Group 4 as compared to the positive control. Aspartate aminotransferase (AST) was significantly (p<0.05) decrease in Group 3, Group 4 and Group 5 as compared to the negative and positive controls. Data from the study suggests hepatoprotective potentials of garlic, garden egg and groundnut.


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