Diabetes is the most common endocrine disease which blood sugar and fat increases followed. Research has shown that some plant extracts have anti-diabetic and so people with diabetes to lower blood sugar, be used therefore, in this study it was decided to establish an experimental diabetic rats, the same situation occurs with type 1diabetes in rats. And the impact of diabetes, hypo-glycemic effect of hydro alcoholic extract of leaves, pumpkins (Cucurbita ficifolia) and metabolic changes in glucose, triglycerides and total cholesterol lipoproteins tend nous be reviewed. In this study rats were divided into 3 groups of 10 each as follows:1-A control injection of saline (intraperitoneally) 2-Diabetic controls: Alloxan monohydrate injection (intraperitoneally) 120 mg/kg in 3 days, after this period of frequent blood glucose monitoring and diabetes was confirmed).3-Cucurbita ficifolia: injecting Alloxan monohydrate 120 mg/kg (intraperitoneally) at 3 days intermittent. After this period, blood glucose monitoring and diabetes was confirmed after confirmation of diabetes, Injection of ethanol extract of pumpkin leaf 100 mg/kg, intraperitoneally and 5 days was staggering. After 48 hours, animals were anesthetized and blood samples were taken from all groups and levels of glucose, lipoprotein, and total cholesterol and triglycerides were determined by enzymatic kits. The results of ANOVA showed that the leaf extract could decrease serum glucose, triglycerides, and VLDL cholesterol levels in diabetic rats compared with diabetic control group significantly (P=0/001).Cucurbita ficifolia are also significantly HDL (p = 0/12) in the blood of diabetic rats compared with the control group increased. In the extract above, the low level of LDL in diabetic rats compared with controls, but the difference was not significant(p=0/12). Considering the findings that the pumpkin leaves can reduce diabetes Sugar, blood fat used.