Introduction: Matrices of Ambroxol hydrochloride with natural gums like Xanthan gum, Guar gum and ĸ-Carrageenan gum and their combinations at different ratios were done to develop a sustained release dosage form.Matrix tablets were formulated using natural gums like Xanthan gum, Guar gum and ĸ-Carrageenan gum and their combinations at different ratios. The effect of water-soluble and water insoluble excipients such as Lactose, Avicel 102 and Dicalcium phosphate on release profiles of gums and swelling in pH 6.8 phosphate buffer was studied and fitted to various release kinetics models. Accelerated stability studies were conducted as per ICH Guidelines at 40°C/75% RH for 6 months. Xanthan gum and ĸ-Carrageenan gum retarded the drug release more than Guar gum. Avicel 102 and Lactose enhanced the dissolution rate whereas Dicalcium phosphate retarded the drug release. It can be concluded that that utilization of natural gums is an effective system for obtaining sustained release of drugs.